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该剧设定在后末世的废土上，无名氏John Doe（安东尼·麦凯 Anthony Mackie 饰）是一个对过去毫无记忆的送奶工，口齿伶俐，车速也飞快。某次他得到了一个过上更好生活的机会——将一个神秘的包裹运送到后末世世界的荒原中。途中他和凶猛好战的偷车贼Quiet（斯蒂芬妮·比翠丝 Stephanie Beatriz 饰）建立了敌对关系，两人在这条道路上面临各种威胁：野蛮的掠夺者和开冰激凌卡车的精神错乱的小丑（威尔·阿奈特 Will Arnett 配音）。。Gaetan Dugas was openly gay. In early 1980s he contracted what was termed "gay cancer". He provided blood samples and 72 names of his former sex partners. Dugas was demonized for his promiscuity and wrongfully identified as patient zero. (IMDb)。